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Tuesday, May 5, 2020 | History

2 edition of Plasma corticosteroids in mice. found in the catalog.

Plasma corticosteroids in mice.

Solem, J. H.

Plasma corticosteroids in mice.

With special regard to sex difference in adrenocortical responsiveness to exogenous corticotrophin

by Solem, J. H.

  • 48 Want to read
  • 37 Currently reading

Published in Oslo .
Written in English

    Subjects:
  • Corticosterone.,
  • Blood plasma.

  • Edition Notes

    Statementby J. H. Solem.
    SeriesThe Scandinavian journal of clinical & laboratory investigation, v. 18 Supplementum, 93
    Classifications
    LC ClassificationsQP801.H7 S67
    The Physical Object
    Pagination36 p.
    Number of Pages36
    ID Numbers
    Open LibraryOL5572110M
    LC Control Number67081083

    Corticosteroids. Corticosteroids (CSs) are key mediators in the maintenance of normal physiology and in the complex adaptive mechanisms that protect an organism in the setting of internal or external stressors From: Practical Management of Pain (Fifth Edition), Related terms: Corticosteroid; Steroid; Dexamethasone; Azathioprine; Prednisone; Antibiotics.   Corticosteroid binding globulin (CBG, transcortin) has been shown to be expressed in the brain of rat and human species. In this study, we examined the CBG brain expression and cDNA structure in mice, comparing wild-type (Cbg +/+) and Cbg knockout mice (Cbg −/−, obtained by genetic disruption of the SerpinA6 alias Cbg gene). We used double immunofluorescence labeling with Cited by:

    Rats, mice, birds, reptiles, and amphibians have no 17α-hydroxylase activity in the adrenal cortex, and corticosterone (B) is the only glucocorticoid. In humans, B is important as an intermediate product of the reaction to produce aldosterone from pregnenolone. View chapter Purchase book Hydroxycorticosterone.   Prednisone treatment restricts B lymphocyte differentiation into plasma cells in MRL/lpr mice, which may be correlated with the inhibition of IL production and the restoration of the balance Cited by:

      Circulating corticosteroids were measured after a brief electric shock in rats which were manipulated during infancy. When compared to nonmanipulated controls it was found that the manipulated rats showed a significant elevation of corticosteroids as early as 15 seconds after shock, whereas the nonmanipulated subjects did not show a significant elevation of steroids until 5 minutes Cited by:   Corticosteroid injections are performed locally with a view to managing local symptoms but it is important to recognise that the corticosteroid is absorbed from the local site and there is hypothalamic pituitary axis suppression of ACTH and cortisol for up to 4 weeks following the administration of a single injection.


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Plasma corticosteroids in mice by Solem, J. H. Download PDF EPUB FB2

Scand J Clin Lab Invest Suppl. ;Suppl Plasma corticosteroids in mice, with special regard to sex difference in adrenocortical responsiveness to exogenous by: Plasma corticosteroids in mice, with special regard to sex difference in adrenocortical responsiveness to exogenous corticotrophin.

Solem JH. Scandinavian Journal of Clinical and Laboratory investigation. Supplementum, 01 JanSuppl PMID: Share this article Share.

PDF ( K) PDF-Plus ( K) Plasma corticosterone, hemoglobin, creatinine and blood urea nitrogen levels, and urinary corticosteroid amounts in mice made hypothermic by exposure to −10 °CCited by: 2.

Corticosteroid levels were studied in the plasma of athymic mice implanted with human breast tumor cells, either from MCF-7 or ZR cell lines. There was a highly significant decrease in plasma corticosterone levels in the mice implanted with these tumor : St.

Lehrer, E. Diamond, H. Kyung Song, W. Bloomer, R. Blumenthal. Avoidance performance and plasma corticosteroid levels in previously undernourished mice. Author links open overlay panel P.D. Leathwood M.S. BushCited by: 1. Plasma corticosterone levels in mouse models of pain.

C57BL/6 mice had their plasma corticosterone levels back to naïve values, Plasma corticosterone levels in mouse M. Benedetti et al. Corticosteroid levels were studied in the plasma of athymic mice implanted with human breast tumor cells, either from MCF-7 or ZR cell lines.

bound and free corticosteroid in the plasma of two subspecies of deer mice (peromyscus maniculatus) after exposure to a low ambient temperature. eleftheriou be. j endocrinol,01 nov cited by 8 articles | pmid: Low-dose corticosteroids may provide a favorable benefit/risk ratio for many therapeutic applications.

However, the extremely low plasma drug concentrations achieved, in conjunction with the insufficient sensitivity/ selectivity of current analytical methods, renders the evaluation of corticosteroid pharmacokinetics (PK) a significant challenge under such by:   Plasma levels of corticosteroids, catecholamines, and electrolytes in controls (intact) and ADX male mice In order to evaluate whether surgical removal of the adrenal glands leads to a sustained decrease in circulating corticosteroids and catecholamines, blood samples from controls and ADX mice Cited by: Corticosteroid binding globulin (CBG) is the major transport protein for glucocorticoids in plasma of mammalian species, with more than 90% of circulating corticosteroid molecules being bound by this carrier (2, 11, 24).Cited by: However, in studies in mice treated with antibody to CRF, there were small increases in plasma corticosterone following intraperitoneal IL-1 (Dunn, a), and similar small, but statistically significant, increases were also observed in CRF-knockout mice (Dunn and Swiergiel, ).

This suggests that when the functions of higher levels of the HPA axis are impaired, the pituitary and/or adrenal cortex. PHARMACOKINETICS AND PHARMACODYNAMICS OF CORTICOSTEROID PRODRUGS AND SOFT DRUGS By Julia Winkler December Chair: Hartmut Derendorf Cochair: Nicholas Bodor Major Department: Pharmaceutics The overall objective of this work is to show that the administration of corticosteroid prodrugs and soft drugs facilitates the use of corticosteroids for.

Ide et al. observed significant elevations in plasma corticosterone in mice subjected to forced-swimming for 6 min per day for five consecutive days. Furthermore, Cavigelli and McClintock [ 31 ] found that serum corticosterone in rats exposed to a 5-min exploration-arena test or to a min restraint did not reach the highest level until 40 min after the end of the by: To determine whether corticosteroids could prevent the development of allergen-induced airway remodeling, different groups of mice (16 mice/group) were administered either dexamethasone (1 mg/kg in μl of sterile, endotoxin-free PBS) or diluent control ip.

The first dose of corticosteroid or diluent was administered 6 h before the first Cited by: The measurement of fecal steroids provides an increasingly important noninvasive technique for assessing reproduction, environmental stress, and aggression in populations of captive and free-living animals.

In this paper, we validated the. The mice are 8 months old when we take the samples. The levels of steroids are much lower than in mice aged 8 weeks. But this is also true of the ad lib fed groups. Corticosteroids in Acute Lung Injury: The Dilemma Continues Daniela Mokra, 1, 2, * Pavol Mikolka, 1, 2 Petra Kosutova, 1, 2 and Juraj Mokry 2, 3 Daniela MokraCited by: 1.

Topical Corticosteroids: Pharmacology Swiss albino mice were used in this experiment imiquimod 5% cream applied on shaved back of mice for six days, and this is an induction group and compared. Corticosteroids may be helpful in cases of complicated infectious mononucleosis.

Tonsillar enlargement that causes airway compromise may respond rapidly to corticosteroids, eliminating the need for tracheostomy. Corticosteroids may also be helpful in autoimmune hemolytic anemia, severe thrombocytopenia, and aplastic anemia.

Its plasma concentrations are normally relatively constant and approximately times greater than those of the other major steroid-binding proteins (Dunn et al.

). However, albumin’s affinity for steroids is 3–4 orders of magnitude lower than those of CBG or SHBG (Dunn et al. ), the plasma concentrations of which undergo much greater fluctuations than albumin, as will be Cited by: Since plasma proteins such as corticosteroid-binding globulin (CBG) and albumin bind a large fraction of circulating steroids, we predicted that steroid concentrations would be high in plasma, intermediate in whole blood, and low in RBC (when equal volumes of each sample type were assayed).

In Study 2 and mice, in which E 2 and Cited by:   Introduction. Recently, liquid chromatography–tandem mass spectrometry (LC–MS) has played a key role in bioanalytical laboratories for the quantification of small molecule drugs, their metabolites and other xenobiotic compounds from biological samples including plasma, blood, serum, urine and tissue ().LC–MS with triple quadrupole mass spectrometry (MS), which has been the Cited by: 4.